Endotypic Determinants of Treatment Success in Obstructive Sleep Apnea

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This webinar will provide an in-depth overview of the physiological endotypes of obstructive sleep apnea (OSA) and how these underlying mechanisms influence treatment response. We will discuss key traits such as anatomy, upper-airway muscle responsiveness, arousal threshold, and ventilatory control stability, and explore how these endotypes can be used to personalize therapy. Clinical applications will include predicting response to oral appliance therapy, hypoglossal nerve stimulation, positional therapy, and pharmacologic approaches.

Learning Objectives:

Define and describe the major physiological endotypes of OSA, including anatomical compromise, muscle responsiveness, arousal threshold, and loop gain
Explain how endotypic traits contribute to OSA treatment responses
Identify which endotypes are associated with improved or reduced treatment success for interventions such as oral appliance therapy and hypoglossal nerve stimulation
Apply endotype-based reasoning to inform clinical decision-making and enhance treatment selection and patient counseling

Joao Luiz Gomes Carneiro Monteiro, DDS, PhD

I am currently a Postdoctoral Research Fellow at the Division of Sleep and Circadian Disorders at Brigham and Women's Hospital and Harvard Medical School. My academic and clinical background includes training in Oral and Maxillofacial Surgery, which has shaped my strong interest in evidence-based medicine and the development of minimally invasive treatments for a wide spectrum of craniomaxillofacial conditions.

Under the mentorship of my supervisors, my current research focuses on obstructive sleep apnea (OSA), particularly in understanding the underlying mechanisms that contribute to the disorder, such as different endotypes, and evaluating the outcomes of pharmacological and non-pharmacological treatments.

Looking ahead, I aspire to pursue a career as a surgeon-scientist. I am especially interested in exploring how minimally invasive surgical therapies can be effectively combined with non-surgical approaches to optimize treatment outcomes.

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Dr. Monteiro reported no financial conflicts of interest.